The psychoactive effects of codeine can vary significantly based on individual tolerance, body weight, and overall health. Generally, therapeutic doses of codeine for pain relief are lower than doses that might produce psychoactive effects. In adults, dosages typically range from 15 mg to 60 mg every 4 to 6 hours as needed for pain, but some individuals may begin to experience psychoactive effects at doses as low as 30 mg to 60 mg.
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